Penetration into the middle ear of four antibiotics commonly used in treatment of otitis media was studied by administering a single oral dose of amoxicillin. pharmacokinetic studies on antibiotic penetration into middle ear effusion (MEE) are difficult Key words: Otitis media, pharmacokinetics, middle ear, antibiotics.
In , a larger study was published, which described characteristics of the penetration of an antibiotic through the middle-ear mucosa, not only in the first. Are antibiotics (topical or oral) effective in acute otitis media and ear They are also well-absorbed with good penetration into the tissue.
Wider uptake with inflammation (CSF, Middle ear, etc) Do not use any B-lactam antibiotic poor CSF penetration even with inflammation. For further information, see 'Table 1: topical antibiotic ear drops'. is very swollen, ear drops cannot penetrate sufficiently down the ear canal to be effective .